Intratumoral gamma-linoleic acid therapy of human gliomas.
نویسندگان
چکیده
In vitro and in vivo studies have shown that gamma-linoleic acid (GLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can selectively kill tumor cells. In a clinical trial, the effectiveness of intratumoral administration of GLA in patients with gliomas was studied. Of the 6 patients treated, all showed substantial response to GLA as documented by computerized tomography. There were no acute side-effects due to the therapy. This report demonstrates that intratumoral administration of GLA is a possible approach to the treatment of human glial tumors.
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ورودعنوان ژورنال:
- Prostaglandins, leukotrienes, and essential fatty acids
دوره 45 3 شماره
صفحات -
تاریخ انتشار 1992